What should be avoided when preparing High-Risk CSPs?

When preparing High-Risk Compounded Sterile Preparations (CSPs), it is essential to maintain a sterile environment to ensure the safety and efficacy of the medication. Avoiding the use of non-sterile components or environments is critical in this context since High-Risk CSPs include preparations that have a higher probability of contamination due to their nature, such as those that involve multiple ingredients or complex preparation processes.

Using non-sterile components can introduce harmful microorganisms into the final product, leading to potential patient infections or adverse effects. Therefore, ensuring that all materials are sterile, working in an appropriate cleanroom environment (like ISO class 5), and taking proper aseptic precautions are crucial practices that should be maintained during the preparation of these high-risk medications. Thus, the emphasis on avoiding non-sterile materials or environments directly correlates with the need to safeguard patient health by reducing the risk of contamination.